High resolution mass spectrometry to investigate the human exposome: Where are We? | Exposome | Oxford Academic
Begoña Talavera Andújar, Emma L Schymanski, High resolution mass spectrometry to investigate the human exposome: Where are We?, Exposome, Volume 6, Issue 1, 2026, osaf017, https://doi.org/10.1093/exposome/osaf017 Begoña Talavera Andújar, Emma L Schymanski, High resolution mass spectrometry to investigate the human exposome: Where are We?, Exposome, Volume 6, Issue 1, 2026, osaf017, https://doi.org/10.1093/exposome/osaf017 Despite the significant role of the environment in health and disease, the accurate assessment of environmental exposures remains underdeveloped compared to genetic factors. To address this, the concept of the exposome was introduced in 2005 as a complement to the genome. High-resolution mass-spectrometry (HRMS) has emerged as a key technology for the comprehensive assessment of the chemical exposome. However, non-target HRMS based exposomics still faces numerous challenges, with the majority of features detected by HRMS (the “dark matter” of the chemical exposome)