Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux | Nature Communications

Lysosomal function depends upon calcium homeostasis. Here, using a novel sensor for perilysosomal pH and lysosomal proton efflux, Chen et al. identify lysosomal TMEM165 as a mediator of the calcium-activated lysosomal proton leak.

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