The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium | Cardiovascular Engineering and Technology

Slider with three content items shown per slide. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Joachim Wegener & Jochen Seebach SongPeng Zhang, XiangJun Zhang, … Herbert Lipowsky 2841 Accesses 9 Citations Explore all metrics Cite this article Transport of water and solutes across vascular endothelium is important in normal physiology and critical in the development of various diseases, including atherosclerosis. However, there is debate about the routes for such transport. We recently showed that an albumin-sized tracer crossed endothelium at bicellular and tricellular junctions, a tracer having the size of high density lipoprotein crossed only through tricellular junctions, and a tracer with the size of low density lipoprotein was unable to cross by either route and instead traversed the cells themselves. Here we review previous work on the structure and function of tricellular junctions. We then des

The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium John Tarbell Open access Published: 20 August 2020 Volume 12 , pages 101–113 ( 2021 ) Cite this article You have full access to this open access article Download PDF Save article View saved research Cardiovascular Engineering and Technology Aims and scope Submit manuscript The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium Download PDF Abstract Purpose Transport of water and solutes across vascular endothelium is important in normal physiology and critical in the develop

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