Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation - PubMed
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The prostate epithelial lineage hierarchy and the cellular origin for prostate cancer remain inadequately defined. Using a lineage-tracing approach, we show that adult rodent prostate basal and luminal cells are independently self-sustained in vivo. Disrupting the tumor suppressor Pten in either lin …