define streptozotocin - Google Search
Skip to main content Accessibility help AI Mode All Images Videos Forums Short videos News More Tools Search Results AI Overview Streptozotocin (also known as streptozocin or STZ) is a naturally occurring chemical compound produced by the soil bacterium [Streptomyces achromogenes] that acts as an antibiotic, an alkylating antineoplastic agent, and a potent toxin to the insulin-producing beta cells of the pancreas. ScienceDirect.com +2 Key Uses Diabetes Research: Scientists use streptozotocin in medical research to induce experimental type 1 or type 2 diabetes in laboratory animals (such as rodents). It enters beta cells through the GLUT2 glucose transporter and damages their DNA. Cancer Treatment: It is used as a chemotherapy drug (under the brand name Zanosar) to treat specific types of cancerous neuroendocrine tumors in the pancreas, specifically malignant metastatic islet cell tumors of the islets of Langerhans. Antibiotic Properties: It exhibits mild broad-spectrum antibiotic act