data-driven evaluation of optimization techniques in cell culture media | Bioinformatics | Oxford Academic
Ali Parsaee, Miranda Stahn, Arian Amirvaresi, Reza Ovissipour, David Staszak, A data-driven evaluation of optimization techniques in cell culture media, Bioinformatics, Volume 42, Issue 9, September 2026, btag607, https://doi.org/10.1093/bioinformatics/btag607 Ali Parsaee, Miranda Stahn, Arian Amirvaresi, Reza Ovissipour, David Staszak, A data-driven evaluation of optimization techniques in cell culture media, Bioinformatics, Volume 42, Issue 9, September 2026, btag607, https://doi.org/10.1093/bioinformatics/btag607 Optimizing cell-culture media for cultivated meat and cellular agriculture is both experimentally demanding and expensive. Traditional approaches use Design of Experiments (DOE) to iterate through candidate formulations until a satisfactory medium emerges. Data-driven methods, and in particular Bayesian optimization (BO), can reach higher objective function values (here, titer) with fewer evaluations than classical DOE. Prior comparisons of optimizers on cell-media data h