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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability | Nature Cell Biology

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Mitochondria are found to fuse at the onset of autophagy. This event, which is regulated by a cyclic AMP–PKA (protein kinase A) signalling pathway, increases ATP synthase activity to prevent starvation-induced cell death.

Subjects Macroautophagy Mitochondria Abstract A plethora of cellular processes, including apoptosis, depend on regulated changes in mitochondrial shape and ultrastructure. The role of mitochondria and of their morphology during autophagy, a bulk degradation and recycling process of eukaryotic cells’ constituents, is not well understood. Here we show that mitochondrial morphology determines the cellular response to macroautophagy. When autophagy is triggered, mitochondria elongate in vitro and in vivo . During starvation, cellular cyclic AMP levels increase and protein kinase A (PKA) is activat

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